Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-34902-w.pdf
Reference28 articles.
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2. Furuhashi, M. & Hotamisligil, G. S. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov 7, 489–503, https://doi.org/10.1038/nrd2589 (2008).
3. Rodriguez-Calvo, R. et al. Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease. J Endocrinol 233, R173–R184, https://doi.org/10.1530/JOE-17-0031 (2017).
4. Kralisch, S. & Fasshauer, M. Adipocyte fatty acid binding protein: a novel adipokine involved in the pathogenesis of metabolic and vascular disease? Diabetologia 56, 10–21, https://doi.org/10.1007/s00125-012-2737-4 (2013).
5. Mita, T. et al. FABP4 is secreted from adipocytes by adenyl cyclase-PKA- and guanylyl cyclase-PKG-dependent lipolytic mechanisms. Obesity (Silver Spring) 23, 359–367, https://doi.org/10.1002/oby.20954 (2015).
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