A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals
Author:
Funder
Biotechnology and Biological Sciences Research Council
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-34749-1.pdf
Reference67 articles.
1. Ghisaidoobe, A. et al. Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. ACS. Med. Chem. Lett. 2, 119–123, https://doi.org/10.1021/ml100192b (2011).
2. Lannoo, N., Van Damme, E. J. M., Albenne, C. & Jamet, E. Plant glycobiology—a diverse world of lectins, glycoproteins, glycolipids and glycans. Front. Plant Sci. 5, https://doi.org/10.3389/fpls.2014.00604 (2014).
3. Strasser, R. Plant protein glycosylation. Glycobiology 26, 926–939, https://doi.org/10.1093/glycob/cww023 (2016).
4. Rugen, M. D., Andriotis, V. M. E. & Field, R. A. Small-molecule probes of plant glycopolymer metabolism in Ref. Mod. Chem. Mol. Sci. and Chem. Eng. Elsevier, (2017).
5. Msanne, J. et al. Glucosylceramides are critical for cell-type differentiation and organogenesis, but not for cell viability in Arabidopsis. Plant J. 84, 188–201, https://doi.org/10.1111/tpj.13000 (2015).
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