Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars-Reference-Cited by-同舟云学术

Identification of Potent and Selective Glucosylceramide Synthase Inhibitors from a Library of N-Alkylated Iminosugars

Published:2010-12-02 Issue:2 Volume:2 Page:119-123
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Ghisaidoobe Amar¹,Bikker Pieter¹,de Bruijn Arjan C. J.¹,Godschalk Frithjof D.¹,Rogaar Eva¹,Guijt Marieke C.¹,Hagens Peter¹,Halma Jerre M.¹,van't Hart Steven M.¹,Luitjens Stijn B.¹,van Rixel Vincent H. S.¹,Wijzenbroek Mark¹,Zweegers Thor¹,Donker-Koopman Wilma E.²,Strijland Anneke²,Boot Rolf²,van der Marel Gijs¹,Overkleeft Herman S.¹,Aerts Johannes M. F. G.²,van den Berg Richard J. B. H. N.¹

Affiliation:

1. Gorlaeus Laboratories, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

2. Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml100192b

Reference48 articles.

1. Demonstration of a deficiency of glucocerebroside-cleaving enzyme in Gaucher's disease.

2. N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis.