Author:
Warren Travis K.,Kane Christopher D.,Wells Jay,Stuthman Kelly S.,Van Tongeren Sean A.,Garza Nicole L.,Donnelly Ginger,Steffens Jesse,Gomba Laura,Weidner Jessica M.,Norris Sarah,Zeng Xiankun,Bannister Roy,Cihlar Tomas,Bavari Sina,Porter Danielle P.,Iversen Patrick L.
Abstract
AbstractEfficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory lymphoid tissues. We performed a randomized and blinded study to compare outcomes from vehicle-treated and remdesivir-treated rhesus monkeys in a lethal model of infection resulting from aerosolized Ebola virus exposure. Remdesivir treatment initiated 4 days after exposure was associated with a significant survival benefit, significant reduction in serum viral titer, and improvements in clinical pathology biomarker levels and lung histology compared to vehicle treatment. These observations indicate that remdesivir may have value in countering aerosol-induced Ebola virus disease.
Funder
US Army Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense Joint Project Manager for Chemical, Biological, Radiological, and Nuclear Defense Medical under
Publisher
Springer Science and Business Media LLC
Reference54 articles.
1. World Health Organization, Situation report. Ebola Virus Disease. https://apps.who.int/iris/bitstream/handle/10665/208883/ebolasitrep_10Jun2016_eng.pdf;jsessionid=4F7DFD58B3A8FDF69F885F6DF11F4E60?sequence=1. 2016.
2. World Health Organization, Ebola in the Democratic Republic of Congo. Health Emergency Update. https://www.who.int/emergencies/diseases/ebola/drc-2019. 2020.
3. Check Hayden, E. Ebola failures prompt WHO rethink. Nature 521(7551), 137 (2015).
4. Levett, J. Disastrous events and political failures. Prehosp. Disaster Med. 30(3), 227–228 (2015).
5. Ebola: a failure of international collective action. Lancet, 2014. 384(9944):637.
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献