A Critical Assessment of Remdesivir-Reference-Cited by-同舟云学术

A Critical Assessment of Remdesivir

Published:2023-10-31 Issue: Volume:19 Page:
ISSN:1574-8855
Container-title:Current Drug Therapy
language:en
Short-container-title:CDTH

Author:

Chandra Subhash¹,Choudhary Alka N²,Palai Santwana³,Rauf Abdur⁴,Aboul-Enein Hassan Y.⁵

Affiliation:

1. Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, SGRR University, Patel Nagar-248001, Bhubaneswar-751003 Odisha India

2. Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, SGRR University, Patel Nagar-248001, Bhubaneswar-751003 Odisha India;

3. Department of Veterinary, Pharmacology and Toxicology, Odisha University of Agriculture & Technology, Dehradun, Uttarakhand, India

4. Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan

5. Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo 12622, Egypt.

Abstract

Abstract: The COVID-19 pandemic that originated in Wuhan city, China, has affected every village in India. This has killed millions of people. This disease involves symptomatic and asymptomatic mutations. The purpose of this review was to assess the effectiveness of remdesivir particularly against SAR-CoV-2 (Coronaviridae family). The relevant works have been studied with respect to the drug's chemistry, mechanism of action, pharmacokinetics, pharmacodynamics, clinical data, and side effects. Remdesivir has been used in many cases of coronavirus-infected patients because it has been proven to possess beneficial effects; however, significant adverse effects have also been reported. Remdesivir has been reported to help in lowering the disease's high fatality rate. However, the WHO has warned against using the medicine because there is no clinical data to support its therapeutic efficacy.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics