Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-21100-x.pdf
Reference32 articles.
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4. Mayne, C. G. et al. The cellular membrane as a mediator for small molecule interaction with membrane proteins. Biochimica et biophysica acta, https://doi.org/10.1016/j.bbamem.2016.04.016 (2016).
5. Sykes, D. A. et al. Observed drug-receptor association rates are governed by membrane affinity: the importance of establishing “micro-pharmacokinetic/pharmacodynamic relationships” at the beta2-adrenoceptor. Molecular pharmacology 85, 608–617, https://doi.org/10.1124/mol.113.090209 (2014).
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