Addressing the Opioids Lipophilicity Challenge via a Straightforward and Simultaneous 1H NMR-Based logP/D Determination, Both Separately and in Mixtures-Reference-Cited by-同舟云学术

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Addressing the Opioids Lipophilicity Challenge via a Straightforward and Simultaneous ¹H NMR-Based logP/D Determination, Both Separately and in Mixtures

Published:2024-07-16 Issue:14 Volume:67 Page:12399-12409
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yeffet Dina¹^ORCID,Columbus Ishay¹^ORCID,Parvari Galit²^ORCID,Eichen Yoav²^ORCID,Saphier Sigal¹^ORCID,Ghindes-Azaria Lee¹^ORCID,Redy-Keisar Orit¹^ORCID,Amir Dafna¹^ORCID,Drug Eyal³^ORCID,Gershonov Eytan¹,Binyamin Iris¹,Cohen Yoram⁴^ORCID,Karton-Lifshin Naama¹,Zafrani Yossi¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Israel Institute for Biological Research, Ness-Ziona 74100, Israel

2. Schulich Faculty of Chemistry Technion, Israel Institute of Technology, Technion City, Haifa 3200008, Israel

3. Department of Analytical Chemistry, Israel Institute for Biological Research, Ness-Ziona 74100, Israel

4. School of Chemistry, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel

Funder

Israeli Prime Minister's office

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c01153

Reference43 articles.

1. Responding to the opioid crisis in North America and beyond: recommendations of the Stanford–Lancet Commission

2. Countermeasures for Preventing and Treating Opioid Overdose

3. The influence of drug-like concepts on decision-making in medicinal chemistry

4. DARK Classics in Chemical Neuroscience: Fentanyl

5. Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes

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