mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis-Reference-Cited by-同舟云学术

mRNA vaccination of rabbits alters the fecundity, but not the attachment, of adult Ixodes scapularis

Published:2024-01-04 Issue:1 Volume:14 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Matias Jaqueline,Cui Yingjun,Lynn Geoffrey E.,DePonte Kathleen,Mesquita Emily,Muramatsu Hiromi,Alameh Mohamad G.,Dwivedi Garima,Tam Ying K.,Pardi Norbert,Weissman Drew,Fikrig Erol

Abstract

Abstract19ISP is a nucleoside-modified mRNA-lipid nanoparticle vaccine that targets 19 Ixodes scapularis proteins. We demonstrate that adult I. scapularis have impaired fecundity when allowed to engorge on 19ISP-immunized rabbits. 19ISP, therefore, has the potential to interrupt the tick reproductive cycle, without triggering some of the other effects associated with acquired tick resistance. This may lead to the development of new strategies to reduce I. scapularis populations in endemic areas.

Funder

National Institutes of Health

Howard Hughes Medical Institute

Steven and Alexandra Cohen Foundation

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41598-023-50389-6.pdf

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