Author:
Hall Andrew J.,Robertson Amy G.,Hill Leila R.,Rendina Louis M.
Abstract
AbstractThe synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents.
Funder
Australian Research Council
Publisher
Springer Science and Business Media LLC
Reference48 articles.
1. Ross, M. F. et al. Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology. Biochemistry 70, 222–230. https://doi.org/10.1007/s10541-005-0104-5 (2005).
2. Rideout, D. C., Calogeropoulou, T., Jaworski, J. S., Dagnino, R. Jr. & McCarthy, M. R. Phosphonium salts exhibiting selective anti-carcinoma activity in vitro. Anticancer Drug Des. 4, 265–280 (1989).
3. Madar, I., Weiss, L. & Izbicki, G. Preferential accumulation of 3H-tetraphenylphosphonium in non-small cell lung carcinoma in mice: Comparison with 99mTc-MIBI. J. Nucl. Med. 43, 234–238 (2002).
4. Liberman, E. A., Topaly, V. P., Tsofina, L. M., Jasaitis, A. A. & Skulachev, V. P. Mechanism of coupling of oxidative phosphorylation and the membrane potential of mitochondria. Nature 222, 1076–1078. https://doi.org/10.1038/2221076a0 (1969).
5. Bakeeva, L. E. et al. Conversion of biomembrane-produced energy into electric form. II. Intact mitochondria. BBA Bioenergetics 216, 13–21, https://doi.org/10.1016/0005-2728(70)90154-4 (1970).
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