Affiliation:
1. School of Chemistry The University of Sydney Sydney NSW 2006 Australia
2. Nano Institute Sydney NSW 2006 Australia
Abstract
AbstractThe synthesis and characterization of a novel trinuclear rhodamine‐Gd(III) complex, along with two analogous mononuclear rhodamine‐Gd(III) complexes, are reported. All complexes displayed good selectivity in a human glioma cell line (T98G) when compared to a glial cell line (SVG p12), with low cytotoxicities. Superior tumor cell uptake for these Gd(III) complexes was observed at lower incubation concentrations compared to previously‐reported delocalized lipophilic cations such as a rhodamine‐lanthanoid(III) probe and Gd(III)‐arylphosphonium complexes, with ca. 150 % and 250 % increases in Gd uptake, respectively.