Author:
Kotepui Manas,Mahittikorn Aongart,Anabire Nsoh Godwin,Kotepui Kwuntida Uthaisar
Abstract
AbstractThe primary antioxidant, glutathione peroxidase (GPx), is hypothesized to contribute to the pathophysiology of malaria. This current study conducted a meta-analysis to examine variations in GPx blood levels in malaria patients. Seven electronic databases—ProQuest, Scopus, Embase, MEDLINE, PubMed, Ovid, and Google Scholar—were searched for relevant studies with no limitations to publication language or publication date. The Joanna Briggs Institute critical appraisal tools were used to appraise the risk of bias among the included studies critically. The meta-analysis was conducted by pooling the effect estimates and Hedges’s g using a random-effects model. Search results returned 1253 articles, of which 16 studies were used for syntheses. Results of the meta-analysis indicated that malaria patients had decreased blood levels of GPx compared to uninfected individuals (P < 0.01, Hedges’ g: − 4.06, 95% CI − 5.49–(− 2.63), I2: 99.07%, 1278 malaria patients/627 uninfected individuals, 15 studies). Subgroup analyses indicated that peripheral levels of GPx were significantly diminished in patients with P. falciparum malaria compared to uninfected controls (P < 0.01, Hedges’ g: − 3.06, 95% CI − 4.46–(− 1.65), I2: 98.39%, 9 studies) but not in patients with P. vivax malaria (P = 0.15, Hedges’ g: − 2.05, 95% CI − 4.83–0.74), I2: 98.64%, 2 studies) Overall, malaria is associated with declined levels of GPx, particularly in patients with P. falciparum malaria. The finding provides valuable insights that prompt the need to investigate the role of GPx depletion in malaria pathogenesis.
Publisher
Springer Science and Business Media LLC
Reference47 articles.
1. WHO. World malaria report 2022. https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2022. Accessed 23 June 2023.
2. Phyo, A. P., Dahal, P., Mayxay, M. & Ashley, E. A. Clinical impact of vivax malaria: A collection review. PLoS Med. 19(1), e1003890 (2022).
3. Lee, W. C. et al. Plasmodium knowlesi: The game changer for malaria eradication. Malar. J. 21(1), 140 (2022).
4. Driss, A. et al. Genetic polymorphisms linked to susceptibility to malaria. Malar. J. 10, 271 (2011).
5. Long, C. A. & Zavala, F. Immune responses in malaria. Cold Spring Harb. Perspect Med. 7(8), a025577 (2017).
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献