Sites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-22959-6.pdf
Reference72 articles.
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3. Van Goor, F. et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci USA 106, 18825–18830, https://doi.org/10.1073/pnas.0904709106 (2009).
4. Moran, O. The gating of the CFTR channel. Cell Mol Life Sci 74, 85–92, https://doi.org/10.1007/s00018-016-2390-z (2017).
5. Cheng, S. H. et al. Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel. Cell 66, 1027–1036 (1991).
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