The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket-Reference-Cited by-同舟云学术

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The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket

Published:2017-08-10 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Thomas Anu,Sulli Chidananda,Davidson Edgar,Berdougo Eli,Phillips Morganne,Puffer Bridget A.,Paes Cheryl,Doranz Benjamin J.,Rucker Joseph B.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-017-07256-y.pdf

Reference50 articles.

1. Conte, C., Ebeling, M., Marcuz, A., Nef, P. & Andres-Barquin, P. J. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Cytogenet Genome Res 98, 45–53 (2002).

2. Chandrashekar, J. et al. T2Rs function as bitter taste receptors. Cell 100, 703–711 (2000).

3. Drewnowski, A. & Gomez-Carneros, C. Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr 72, 1424–1435 (2000).

4. Bufe, B., Hofmann, T., Krautwurst, D., Raguse, J.-D. & Meyerhof, W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet 32, 397–401, doi: 10.1038/ng1014 (2002).

5. Meyerhof, W. et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35, 157–170 (2010).

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