Flux balance analysis with or without molecular crowding fails to predict two thirds of experimentally observed epistasis in yeast
Author:
Funder
Deutscher Akademischer Austauschdienst
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-47935-6.pdf
Reference55 articles.
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2. Hartman, J. L. T., Garvik, B. & Hartwell, L. Principles for the buffering of genetic variation. Science (New York, N.Y.) 291, 1001–1004 (2001).
3. Boone, C., Bussey, H. & Andrews, B. J. Exploring genetic interactions and networks with yeast. Nature reviews. Genetics 8, 437–449, https://doi.org/10.1038/nrg2085 (2007).
4. Phillips, P. C. Epistasis–the essential role of gene interactions in the structure and evolution of genetic systems. Nature reviews. Genetics 9, 855–867, https://doi.org/10.1038/nrg2452 (2008).
5. Kondrashov, A. S. Selection against harmful mutations in large sexual and asexual populations. Genetical research 40, 325–332 (1982).
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