Significance of NS5B Substitutions in Genotype 1b Hepatitis C Virus Evaluated by Bioinformatics Analysis-Reference-Cited by-同舟云学术

Significance of NS5B Substitutions in Genotype 1b Hepatitis C Virus Evaluated by Bioinformatics Analysis

Published:2018-06-11 Issue:1 Volume:8 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Uchida Yoshihito,Nakamura Shugo,Kouyama Jun-Ichi,Naiki Kayoko,Motoya Daisuke,Sugawara Kayoko,Inao Mie,Imai Yukinori,Nakayama Nobuaki,Tomiya Tomoaki,Hedskog Charlotte,Brainard Diana,Mo Hongmei,Mochida Satoshi

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-27291-7.pdf

Reference44 articles.

1. Kumada, H. et al. Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection. Hepatology. 59, 2083–2091 (2014).

2. Uchida, Y. et al. A novel simple assay system to quantify the percent HCV-RNA levels of NS5A Y93H mutant strains and Y93 wild-type strains relative to the total HCV-RNA levels to determine the indication for antiviral therapy with NS5A inhibitors. PLoS One. 149, e112647 (2014).

3. Uchida, Y. et al. Significance of variants associated with resistance to NS5A inhibitors in Japanese patients with genotype 1b hepatitis C virus infection as evaluated using cycling-probe real-time PCR combined with direct sequencing. J Gastroenterol 51, 260–270 (2016).

4. Yoshimi, S. et al. Rapid, sensitive, and accurate evaluation of drug resistant mutant (NS5A-Y93H) strain frequency in genotype 1b HCV by invader assay. PLoS One 10, e0130022 (2015).

5. Uchida, Y. et al. Development of rare resistance-associated variants that are extremely tolerant against NS5A inhibitors during daclatasvir/asunaprevir therapy by a two-hit mechanism. Hepatol Res 46, 1234–1246 (2016).

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