Development of rare resistance-associated variants that are extremely tolerant against NS5A inhibitors during daclatasvir/asunaprevir therapy by a two-hit mechanism
Author:
Affiliation:
1. Department of Gastroenterology and Hepatology, Faculty of Medicine; Saitama Medical University; Moroyama Japan
Publisher
Wiley
Subject
Infectious Diseases,Hepatology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/hepr.12673/fullpdf
Reference17 articles.
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2. Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options;Suzuki;J Hepatol,2013
3. Daclatasvir plus asnaprevir for chronic HCV genotype 1b infection;Kumada;Hepatology,2014
4. A novel simple assay system to quantify the percent HCV-RNA levels of NS5A Y93H mutant strains and Y93 wild-type strains relative to the total HCV-RNA levels to determine the indication for antiviral therapy with NS5A inhibitors;Uchida;PLoS One,2014
5. Significance of variants associated with resistance to NS5A inhibitors in Japanese patients with genotype 1b hepatitis C virus infection as evaluated using cycling-probe real-time PCR combined with direct sequencing;Uchida;J Gastroenterol,2016
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