Label-free X-ray estimation of brain amyloid burden-Reference-Cited by-同舟云学术

Label-free X-ray estimation of brain amyloid burden

Published:2020-11-25 Issue:1 Volume:10 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Dahal Eshan,Ghammraoui Bahaa,Ye Meijun,Smith J. Carson,Badano Aldo

Abstract

AbstractAmyloid plaque deposits in the brain are indicative of Alzheimer’s and other diseases. Measurements of brain amyloid burden in small animals require laborious post-mortem histological analysis or resource-intensive, contrast-enhanced imaging techniques. We describe a label-free method based on spectral small-angle X-ray scattering with a polychromatic beam for in vivo estimation of brain amyloid burden. Our findings comparing 5XFAD versus wild-type mice correlate well with histology, showing promise for a fast and practical in vivo technique.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-020-77554-5.pdf

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