Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients

Author:

Solana Elisabeth,Martinez-Heras Eloy,Montal Victor,Vilaplana Eduard,Lopez-Soley Elisabet,Radua Joaquim,Sola-Valls Nuria,Montejo Carmen,Blanco Yolanda,Pulido-Valdeolivas Irene,Sepúlveda Maria,Andorra Magi,Berenguer Joan,Villoslada Pablo,Martinez-Lapiscina E. H.,Prados Ferran,Saiz Albert,Fortea Juan,Llufriu Sara

Abstract

AbstractThe spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a new surface-based diffusion MRI processing tool to investigate regional modifications of microstructure, and we quantified volume loss in GM in a cohort of patients with MS classified into three groups according to disease duration. Additionally, we investigated the relationship between GM changes with disease severity. We studied 54 healthy controls and 247 MS patients classified regarding disease duration: MS1 (less than 5 years, n = 67); MS2 (5–15 years, n = 107); and MS3 (more than15 years, n = 73). We compared GM mean diffusivity (MD), fractional anisotropy (FA) and volume between groups, and estimated their clinical associations. Regional modifications in diffusion measures (MD and FA) and volume did not overlap early in the disease, and became widespread in later phases. We found higher MD in MS1 group, mainly in the temporal cortex, and volume reduction in deep GM and left precuneus. Additional MD changes were evident in cingulate and occipital cortices in the MS2 group, coupled to volume reductions in deep GM and parietal and frontal poles. Changes in MD and volume extended to more than 80% of regions in MS3 group. Conversely, increments in FA, with very low effect size, were observed in the parietal cortex and thalamus in MS1 and MS2 groups, and extended to the frontal lobe in the later group. MD and GM changes were associated with white matter lesion load and with physical and cognitive disability. Microstructural integrity loss and atrophy present differential spatial predominance early in MS and accrual over time, probably due to distinct pathogenic mechanisms that underlie tissue damage.

Funder

Ayudas Merck de Investigación

Proyecto Societat Catalana Neurologia

Proyecto de Investigación en Salud

Red Española de Esclerosis Múltiple

TEVA Spain

CIBERNED program

National Institutes of Health

Fundació la Marató de TV3

Fundació Catalana Síndrome de Down

Fundació Víctor Grífols i Lucas

Generalitat de Catalunya

University of Barcelona

Hospital Clinic Emili Letang

MS Innovation GMSI

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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