Fecal microbiota transplantation from warthog to pig confirms the influence of the gut microbiota on African swine fever susceptibility

Author:

Zhang Jinya,Rodríguez Fernando,Navas Maria Jesus,Costa-Hurtado Mar,Almagro Vanessa,Bosch-Camós Laia,López Elisabeth,Cuadrado Raul,Accensi Francesc,Pina-Pedrero Sonia,Martínez Jorge,Correa-Fiz Florencia

Abstract

AbstractAfrican swine fever virus (ASFV) is the causative agent of a devastating hemorrhagic disease (ASF) that affects both domestic pigs and wild boars. Conversely, ASFV circulates in a subclinical manner in African wild pigs, including warthogs, the natural reservoir for ASFV. Together with genetic differences, other factors might be involved in the differential susceptibility to ASF observed among Eurasian suids (Sus scrofa) and African warthogs (Phacochoerus africanus). Preliminary evidence obtained in our laboratory and others, seems to confirm the effect that environmental factors might have on ASF infection. Thus, domestic pigs raised in specific pathogen-free (SPF) facilities were extremely susceptible to highly attenuated ASFV strains that were innocuous to genetically identical domestic pigs grown on conventional farms. Since gut microbiota plays important roles in maintaining intestinal homeostasis, regulating immune system maturation and the functionality of the innate/adaptive immune responses, we decided to examine whether warthog fecal microbiota transplantation (FMT) to domestic pigs affects host susceptibility to ASFV. The present work demonstrates that warthog FMT is not harmful for domestic weaned piglets, while it modifies their gut microbiota; and that FMT from warthogs to pigs confers partial protection against attenuated ASFV strains. Future work is needed to elucidate the protective mechanisms exerted by warthog FMT.

Funder

Chinese Scholarship Council

Ministry of Economy and Competitiveness (MINECO) from the Spanish Government

Juan de la Cierva fellowship from MINECO

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference82 articles.

1. African swine fever: OIE - World Organisation for Animal Health. https://www.oie.int/en/animal-health-in-the-world/animal-diseases/african-swine-fever/.

2. Blome, S., Franzke, K. & Beer, M. African swine fever—A review of current knowledge. Virus Res. 287, 198099 (2020).

3. Wang, N. et al. Architecture of African swine fever virus and implications for viral assembly. Science 366, 640–644 (2019).

4. Dixon, L. K., Chapman, D. A. G., Netherton, C. L. & Upton, C. African swine fever virus replication and genomics. Virus Res. 173, 3–14 (2013).

5. Malmquist, W. A. & Hay, D. Hemadsorption and cytopathic effect produced by African Swine Fever virus in swine bone marrow and buffy coat cultures. Am. J. Vet. Res. 21, 104–108 (1960).

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