Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene-Reference-Cited by-同舟云学术

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Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene

Published:2019-04-30 Issue:1 Volume:9 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Taneja Guncha,Maity Suman,Jiang Weiwu,Moorthy Bhagavatula,Coarfa Cristian,Ghose Romi

Funder

U.S. Department of Health & Human Services | NIH | Center for Scientific Review

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-019-43248-w.pdf

Reference69 articles.

1. Guengerich, F. P. Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu. Rev. Pharmacol. Toxicol. 39, 1–17 (1999).

2. Veith, H. et al. Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries. Nat. Biotechnol. 27, 1050–1055 (2009).

3. Wilkinson, G. R. Drug metabolism and variability among patients in drug response. N. Engl. J. Med. 352, 2211–2221 (2005).

4. Zanger, U. M. & Schwab, M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol. Ther. 138, 103–141 (2013).

5. Zhang, L., Zhang, Y. D., Zhao, P. & Huang, S.-M. Predicting drug-drug interactions: an FDA perspective. AAPS J. 11, 300–306 (2009).

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