Exploring the PXR ligand binding mechanism with advanced Molecular Dynamics methods
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-34373-z.pdf
Reference67 articles.
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3. Biswas, A. et al. Elucidating the ‘Jekyll and Hyde’ nature of PXR: The case for discovering antagonists or allosteric antagonists. Pharm. Res. 26, 1807–1815 (2009).
4. Chai, S. C., Cherian, M. T., Wang, Y.-M. & Chen, T. Small-molecule modulators of PXR and CAR. Biochim. Biophys. Acta 1859, 1141–1154 (2016).
5. Banerjee, M. & Chen, T. Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor. Biochem. Pharmacol. 86, 824–835 (2013).
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