Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1-Reference-Cited by-同舟云学术

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Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Published:2017-03-22 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Parnell Euan,McElroy Stuart P.,Wiejak Jolanta,Baillie Gemma L.,Porter Alison,Adams David R.,Rehmann Holger,Smith Brian O.,Yarwood Stephen J.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-017-00455-7.pdf

Reference40 articles.

1. Bos, J. L. Epac proteins: multi-purpose cAMP targets. Trends Biochem Sci 31, 680–686 (2006).

2. Sands, W. A., Woolson, H. D., Milne, G. R., Rutherford, C. & Palmer, T. M. Exchange protein activated by cyclic AMP (Epac)-mediated induction of suppressor of cytokine signaling 3 (SOCS-3) in vascular endothelial cells. Molecular and cellular biology 26, 6333–6346 (2006).

3. Yarwood, S. J., Borland, G., Sands, W. A. & Palmer, T. M. Identification of CCAAT/enhancer-binding proteins as exchange protein activated by cAMP-activated transcription factors that mediate the induction of the SOCS-3 gene. J Biol Chem. 283, 6843–6853 (2008).

4. Tan, J. C. & Rabkin, R. Suppressors of cytokine signaling in health and disease. Pediatr Nephrol. 20, 567–575 (2005).

5. Sasaki, A. et al. Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain. Genes Cells. 4, 339–351 (1999).

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1. cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment;Journal of Hematology & Oncology;2024-01-17

2. Protein interaction, cytotoxic, transcriptomic and proteomic responses to structurally distinct EPAC1 activators in HUVECs;Scientific Reports;2022-10-05

3. Allosteric regulation of cyclic nucleotide-dependent protein kinases;Canadian Journal of Chemistry;2022-09-01

4. Epac: A Promising Therapeutic Target for Vascular Diseases: A Review;Frontiers in Pharmacology;2022-07-14

5. QSAR models reveal new EPAC-selective allosteric modulators;RSC Chemical Biology;2022

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