QSAR models reveal new EPAC-selective allosteric modulators
Author:
Affiliation:
1. Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, L8S 4L8, Canada
2. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, L8S 4L8, Canada
Abstract
Funder
Natural Sciences and Engineering Research Council of Canada
Canadian Institutes of Health Research
Publisher
Royal Society of Chemistry (RSC)
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2022/CB/D2CB00106C
Reference57 articles.
1. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
2. Mechanism of Regulation of the Epac Family of cAMP-dependent RapGEFs
3. The Epac1 Protein: Pharmacological Modulators, Cardiac Signalosome and Pathophysiology
4. Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1
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