Author:
Bazzocchi Gabriele,Turroni Silvia,Bulzamini Maria Chiara,D’Amico Federica,Bava Angelica,Castiglioni Mirco,Cagnetta Valentina,Losavio Ernesto,Cazzaniga Maurizio,Terenghi Laura,De Palma Luisa,Frasca Giuseppina,Aiachini Beatrice,Cremascoli Sonia,Massone Antonino,Oggerino Claudia,Onesta Maria Pia,Rapisarda Lucia,Pagliacci Maria Cristina,Biscotto Sauro,Scarazzato Michele,Giovannini Tiziana,Balloni Mimosa,Candela Marco,Brigidi Patrizia,Kiekens Carlotte
Abstract
AbstractAfter spinal cord injury (SCI), patients face many physical and psychological issues including intestinal dysfunction and comorbidities, strongly affecting quality of life. The gut microbiota has recently been suggested to influence the course of the disease in these patients. However, to date only two studies have profiled the gut microbiota in SCI patients, months after a traumatic injury. Here we characterized the gut microbiota in a large Italian SCI population, within a short time from a not only traumatic injury. Feces were collected within the first week at the rehabilitation center (no later than 60 days after SCI), and profiled by 16S rRNA gene-based next-generation sequencing. Microbial profiles were compared to those publicly available of healthy age- and gender-matched Italians, and correlated to patient metadata, including type of SCI, spinal unit location, nutrition and concomitant antibiotic therapies. The gut microbiota of SCI patients shows distinct dysbiotic signatures, i.e. increase in potentially pathogenic, pro-inflammatory and mucus-degrading bacteria, and depletion of short-chain fatty acid producers. While robust to most host variables, such dysbiosis varies by lesion level and completeness, with the most neurologically impaired patients showing an even more unbalanced microbial profile. The SCI-related gut microbiome dysbiosis is very likely secondary to injury and closely related to the degree of completeness and severity of the lesion, regardless of etiology and time interval. This microbial layout could variously contribute to increased gut permeability and inflammation, potentially predisposing patients to the onset of severe comorbidities.
Publisher
Springer Science and Business Media LLC
Cited by
31 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献