Author:
Nouioura Ghizlane,El fadili Mohamed,El Barnossi Azeddin,Loukili El Hassania,Laaroussi Hassan,Bouhrim Mohammed,Giesy John P.,Aboul-Soud Mourad A. M.,Al-Sheikh Yazeed A.,Lyoussi Badiaa,Derwich El houssine
Abstract
AbstractAlthough giant fennel is recognized as a “superfood” rich in phytochemicals with antioxidant activity, research into the antibacterial properties of its fruits has been relatively limited, compared to studies involving the root and aerial parts of the plant. In this study, seven solvents—acetone, methanol, ethanol, ethyl acetate, chloroform, water, and hexane—were used to extract the chemical constituents of the fruit of giant fennel (Ferula communis), a species of flowering plant in the carrot family Apiaceae. Specific attributes of these extracts were investigated using in silico simulations and in vitro bioassays. High-performance liquid chromatography equipped with a diode-array detector (HPLC–DAD) identified 15 compounds in giant fennel extract, with p-coumaric acid, 3-hydroxybenzoic acid, sinapic acid, and syringic acid being dominant. Among the solvents tested, ethanol demonstrated superior antioxidant activity and phenolic and flavonoid contents. F. communis extracts showed advanced inhibition of gram-negative pathogens (Escherichia coli and Proteus mirabilis) and variable antifungal activity against tested strains. Molecular docking simulations assessed the antioxidative, antibacterial, and antifungal properties of F. communis, facilitating innovative therapeutic development through predicted compound–protein interactions. In conclusion, the results validate the ethnomedicinal use and potential of F. communis. This highlights its significance in natural product research and ethnopharmacology.
Publisher
Springer Science and Business Media LLC
Reference54 articles.
1. Nouioura, G. et al. Assessment of the acute and subacute toxicity of the aqueous extract of Moroccan Ferula communis fruit in a mouse model. Saudi Pharm. J. 31(8), 101701. https://doi.org/10.1016/j.jsps.2023.101701 (2023).
2. Bellakhdar, J. Médecine traditionnelle et toxicologie ouest-sahariennes: contribution à l’étude de la pharmacopée marocaine (1978).
3. Mrid, R. B. et al. Dittrichia viscosa L. leaves: A valuable source of bioactive compounds with multiple pharmacological effects. Molecules 27(7), 2108. https://doi.org/10.3390/molecules27072108 (2022).
4. El Alaoui Fares, F., Cauwet, A., Fraigui, O., Lamnaouer, D. & Gorenflot, R. Le Genre Ferula L (apiaées) au Maroc. Revu de cytologie et biologie vegetales-le botaniste, 3–19, (2005).
5. Bellakhdar, J. Pharmacopée marocaine traditionnelle: Medicine arabe ancienne et savoirs populaires 739–759 (Ibis Press, 1997).