Abstract
AbstractGastrointestinal nematode infections, including Haemonchus contortus, are one of the main causes of economic losses to ovine farmers worldwide. In order to contribute to the control of nematode infections and avoid parasite spreading we generated divergent resistant and susceptible sheep breeds and evaluated the adaptive immunity of these animals developed upon experimental infection against H. contortus. The selection of resistant or susceptible animals from the Corriedale Breed has been based on Expected Progeny Differences for faecal egg counts per gram. Furthermore, animals from the resistant Corriedale line were inseminated with imported semen from Australian Rylington Merino rams. Thus, the objective of this work was to analyze the adaptive immune response in both susceptible and resistant obtained lambs. Our results indicate that there is a potent parasite-specific local and systemic immune response in resistant animals and that although susceptible lambs can produce high levels of IgA antibodies during the infection, their antibody response is delayed which, together with an impaired specific-Th2 response, does not contribute to initial parasite elimination. Our results shed light into the immune mechanisms that mediate resistance to H. contortus and could constitute important assets to sheep farmers, not only as a means to detect resistance, but also to enhance the efficiency of selection in stud flocks.
Funder
Comisión Sectorial de Investigación Científica
Publisher
Springer Science and Business Media LLC
Reference43 articles.
1. Toscano, J. H. B. et al. Identification of appropriate reference genes for local immune-related studies in Morada Nova sheep infected with Haemonchus contortus. Mol Biol Rep 45, 1253–1262 (2018).
2. Emery, D. L., Hunt, P. W. & Le Jambre, L. F. Haemonchus contortus: the then and now, and where to from here? Int J Parasitol 46, 755–769 (2016).
3. Muchiut, S. M., Fernandez, A. S., Steffan, P. E., Riva, E. & Fiel, C. A. Anthelmintic resistance: Management of parasite refugia for Haemonchus contortus through the replacement of resistant with susceptible populations. Vet Parasitol 254, 43–48 (2018).
4. Castells, D. & Gimeno, D. Selection of Corriedale sheep for resistance or susceptibility to nematode infection in Uruguay. Proceedings: 23rd Int Conf World Assoc Adv Vet Parasitol (WAVVP) (2011).
5. Karlsson, L. J. E. & Greeff, J. C. Selection response in fecal worm egg counts in the Rylington Merino parasite resistant flock. Aus J Exp. Agriculture 46, 809–811 (2006).
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献