Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion-Reference-Cited by-同舟云学术

Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion

Published:2018-11-19 Issue:1 Volume:8 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Scarneo Scott A.,Mansourati Antoine,Eibschutz Liesl S.,Totzke Juliane,Roques Jose R.,Loiselle David,Carlson David^ORCID,Hughes Philip^ORCID,Haystead Timothy A. J.

Funder

U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-35189-7.pdf

Reference49 articles.

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3. Spadaro, A. et al. Remission in ankylosing spondylitis treated with anti-TNF-alpha drugs: a national multicentre study. Rheumatology (Oxford) 52, 1914–1919 (2013).

4. Powrie, F. et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1, 553–562 (1994).

5. Roda, G., Jharap, B., Neeraj, N. & Colombel, J. F. Loss of Response to Anti-TNFs: Definition, Epidemiology, and Management. Clin Transl Gastroenterol 7, e135 (2016).

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