Baseline value of intrahepatic HBV DNA over cccDNA predicts patient’s response to interferon therapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-05242-y.pdf
Reference22 articles.
1. Wang, F. S., Fan, J. G., Zhang, Z., Gao, B. & Wang, H. Y. The global burden of liver disease: the major impact of China. Hepatology 60, 2099–2108 (2014).
2. Dienstag, J. L. Hepatitis B virus infection. N. Engl. J. Med. 359, 1486–1500 (2008).
3. Papatheodoridis, G. V., Manolakopoulos, S., Dusheiko, G. & Archimandritis, A. J. Therapeutic strategies in the management of patients with chronic hepatitis B virus infection. Lancet Infect Dis 8, 167–178 (2008).
4. Nassal, M. HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B. Gut 64, 1972–1984 (2015).
5. Weng, M. et al. Quantification of serum hepatitis B surface antigen in predicting the response of pegylated interferon alfa-2a in HBeAg-positive chronic hepatitis B with prior lamivudine exposure. Virol. J. 10, 277 (2013).
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