Author:
Kurek Joanna,Myszkowski Krzysztof,Okulicz-Kozaryn Irena,Kurant Agnieszka,Kamińska Ewa,Szulc Michał,Rubiś Błażej,Kaczmarek Mariusz,Mikołajczak Przemysław Ł.,Murias Marek
Abstract
Abstract10-Alkylthiocolchicines have been obtained and characterized by spectroscopic methods and their biological activities as: cytotoxic, anti-inflammatory and analgesic activities have been tested. Cytotoxic activity against SKOV-3 ovarian cell line for 10-alkylthiocolchicine analogues was reported and tested compounds showed to be more active than commonly used doxorubicin. Some of tested C-10 alkylthiolated colchicines have been found to exhibit cytotoxicity at levels comparable to that of the natural product—colchicine. 10-Methylthiocolchicine has IC50 = 8 nM and 10-ethylthiocolchicine has IC50 = 47 nM in comparison to colchicine IC50 = 37 nM. Moreover for 10-alkylthioderivatives apoptosis test, cyclin B1 and cell cycle tests were performed. 10-n-Butylthiocolchicine was tested for anti-inflammatory and analgesic activities it showed to produce analgesic rather than anti-inflammatory effect.
Funder
grant Poznan Universities: AMU, PUMS and PULS
Publisher
Springer Science and Business Media LLC
Cited by
6 articles.
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