Animal Models of sepsis: setting the stage
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1854.pdf
Reference107 articles.
1. Angus, D. C. et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29, 1303–1310 (2001). An excellent overview of sepsis epidemiology and associated health-care costs within the United States.
2. Panacek, E. A. et al. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit. Care Med. 32, 2173–2182 (2004). The first successful clinical trial to utilize an endogenous biomarker (IL-6) to stratify patients. Prospectively demonstrated that more accurate patient selection was required to show benefit from therapy
3. Natanson, C., Hoffman, W. D., Suffredini, A. F., Eichacker, P. Q. & Danner, R. L. Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis. Ann. Intern. Med. 120, 771–783 (1994).
4. Riedemann, N. C., Guo, R. F. & Ward, P. A. The enigma of sepsis. J. Clin. Invest. 112, 460–467 (2003).
5. Marshall, J. C. Such stuff as dreams are made on: mediator-directed therapy in sepsis. Nature Rev. Drug Discov. 2, 391–405 (2003). An excellent review of sepsis therapies and human clinical trials.
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