Such stuff as dreams are made on: mediator-directed therapy in sepsis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1084.pdf
Reference161 articles.
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3. Angus, D. C. et al. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29, 1303–1310 (2001). Using administrative data from seven states, and representing a quarter of the US population, this paper provides the best contemporary estimate of the prevalence and clinical and economic impact of sepsis in the United States.
4. Bernard, G. R. et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med. 344, 699–709 (2001). This manuscript reports the results of the pivotal trial of recombinant human activated protein C (drotecogin alpha activated) in sepsis. A statistically significant survival benefit of 6.1% in treated patients led to the first FDA approval of a recombinant protein for the treatment of sepsis.
5. Annane, D. et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288, 862–871 (2002). A multicentre French study that showed a statistically significant survival benefit when patients with vasopressor-dependent septic shock who showed impaired responses to an adrenocorticotropic hormone stimulation test were treated with a combination of hydrocortisone and fludrocortisone.
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