Targeted DNA demethylation in vivo using dCas9–peptide repeat and scFv–TET1 catalytic domain fusions
Author:
Publisher
Springer Science and Business Media LLC
Subject
Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology
Link
http://www.nature.com/articles/nbt.3658.pdf
Reference32 articles.
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3. Bird, A.P. & Wolffe, A.P. Methylation-induced repression--belts, braces, and chromatin. Cell 99, 451–454 (1999).
4. Feinberg, A.P. & Tycko, B. The history of cancer epigenetics. Nat. Rev. Cancer 4, 143–153 (2004).
5. Carey, N., Marques, C.J. & Reik, W. DNA demethylases: a new epigenetic frontier in drug discovery. Drug Discov. Today 16, 683–690 (2011).
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