Sirolimus (rapamycin) for the targeted treatment of the fibrotic sequelae of Graves’ orbitopathy
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Arts and Humanities,Ophthalmology,Sensory Systems
Link
http://www.nature.com/articles/s41433-019-0340-3.pdf
Reference17 articles.
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2. Molina-Molina M, Machahua-Huamani C, Vicens-Zygmunt V, Llatjós R, Escobar I, Sala-Llinas E, et al. Anti-fibrotic effects of pirfenidone and rapamycin in primary IPF fibroblasts and human alveolar epithelial cells. BMC Pulm Med. 2018;18:63.
3. Pritchard J, Horst N, Cruikshank W, Smith TJ. Igs from patients with Graves’ disease induce the expression of T cell chemoattractants in their fibroblasts. J Immunol. 2002;168:942–50.
4. Hillel AT, Gelbard A. Unleashing rapamycin in fibrosis. Oncotarget. 2015;6:15722–3.
5. Ghosh A, Malaisrie N, Leahy KP, Singhal S, Einhorn E, Howlett P, et al. Cellular adaptive inflammation mediates airway granulation in a murine model of subglottic stenosis. Otolaryngol Head Neck Surg. 2011;144:927–33.
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