TCR-pMHC: Envisioning the specialized dynamics of the target 5-component complex
Author:
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Immunology,Immunology and Allergy
Link
https://www.nature.com/articles/s41423-022-00856-3.pdf
Reference15 articles.
1. Hwang W, Mallis RJ, Lang MJ, Reinherz EL. The αβTCR mechanosensor exploits dynamic ectodomain allostery to optimize its ligand recognition site. Proc Natl Acad Sci USA. 2020;117:21336–45. https://doi.org/10.1073/pnas.2005899117
2. Kim ST, Takeuchi K, Sun ZY, Touma M, Castro CE, Fahmy A, et al. The alphabeta T cell receptor is an anisotropic mechanosensor. J Biol Chem. 2009;284:31028–37. https://doi.org/10.1074/jbc.M109.052712
3. Huang J, Zarnitsyna VI, Liu B, Edwards LJ, Jiang N, Evavold BD, et al. The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness. Nature. 2010;464:932–6. https://doi.org/10.1038/nature08944
4. Limozin L, Bridge M, Bongrand P, Dushek O, van der Merwe PA, Robert P. TCR-pMHC kinetics under force in a cell-free system show no intrinsic catch bond, but a minimal encounter duration before binding. Proc Natl Acad Sci USA. 2019;116:16943–48. https://doi.org/10.1073/pnas.1902141116
5. Schütz GJ, Huppa JB. How drag sharpens a T cell’s view on antigen. Proc Natl Acad Sci USA. 2019;116:16669–71. https://doi.org/10.1073/pnas.1911389116
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1. Dichotomy in TCR V-domain dynamics binding the opposed inclined planes of pMHC-II and pMHC-I α-helices;Molecular Immunology;2023-10
2. Dichotomy in TCR V-domain dynamics binding the opposed inclined planes of pMHC-II and pMHC-I α-helices;2023-01-19
3. The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering;International Journal of Molecular Sciences;2022-11-25
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