Tempering of exhausted T cells to comprehend their adaptive response for suitable clinical translation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Immunology,Immunology and Allergy
Link
https://www.nature.com/articles/s41423-023-01031-y.pdf
Reference10 articles.
1. Chow A, Perica K, Klebanoff CA, Wolchok JD. Clinical implications of T cell exhaustion for cancer immunotherapy. Nat Rev Clin Oncol. 2022;19:775–90. https://doi.org/10.1038/s41571-022-00689-z.
2. Wherry EJ, Kurachi M. Molecular and cellular insights into T cell exhaustion. Nat Rev Immunol. 2015;15:486–99. https://doi.org/10.1038/nri3862.
3. Belk JA, Daniel B, Satpathy AT. Epigenetic regulation of T cell exhaustion. Nat Immunol. 2022;23:848–60. https://doi.org/10.1038/s41590-022-01224-z.
4. Vignali PDA, DePeaux K, Watson MJ, Ye C, Ford BR, Lontos K, et al. Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity. Nat Immunol 2023;24:267–79. https://doi.org/10.1038/s41590-022-01379-9. Epub 2022 Dec 21.
5. Saadey AA, Yousif A, Osborne N, Shahinfar R, Chen YL, Laster B, et al. Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy. Nat Immunol 2023;24:280–94. https://doi.org/10.1038/s41590-022-01384-y. Epub 2022 Dec 21.
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