Host Double Strand Break Repair Generates HIV-1 Strains Resistant to CRISPR/Cas9
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep29530.pdf
Reference36 articles.
1. Finzi, D. et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat Med 5, 512–517, 10.1038/8394 (1999).
2. Ebina, H., Misawa, N., Kanemura, Y. & Koyanagi, Y. Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus. Sci Rep 3, 2510 (2013).
3. Hu, W. et al. RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proc Natl Acad Sci USA 111, 11461–11466 (2014).
4. Liao, H. K. et al. Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells. Nat Commun 6, 6413 (2015).
5. Zhu, W. et al. The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA. Retrovirology 12, 22 (2015).
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