Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing-Reference-Cited by-同舟云学术

Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing

Published:2018-07-02 Issue:3 Volume:84 Page:325-327
ISSN:0031-3998
Container-title:Pediatric Research
language:en
Short-container-title:Pediatr Res

Author:

Lewis Tamorah,Van Haandel Leon,Scott Allison,Leeder J Steven

Publisher

Springer Science and Business Media LLC

Subject

Pediatrics, Perinatology and Child Health

Link

http://www.nature.com/articles/s41390-018-0051-7.pdf

Reference6 articles.

1. Kearns, G. L. et al. Developmental pharmacology—drug disposition, action, and therapy in infants and children. N. Engl. J. Med. 349, 1157–1167 (2003).

2. Smyth, J. M. et al. Intravenous indometacin in preterm infants with symptomatic patent ductus arteriosus. A population pharmacokinetic study. Br. J. Clin. Pharmacol. 58, 249–258 (2004).

3. Mano, Y., Usui, T. & Kamimura, H. Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver. Eur. J. Clin. Pharmacol. 63, 289–296 (2007).

4. Nakajima, M. et al. Cytochrome P450 2C9 catalyzes indomethacin O-demethylation in human liver microsomes. Drug Metab. Dispos. 26, 261–266 (1998).

5. Kokki, M. et al. Maturation of oxycodone pharmacokinetics in neonates and infants: oxycodone and its metabolites in plasma and urine. Br. J. Clin. Pharmacol. 83, 791–800 (2017).

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