Production of individualized V gene databases reveals high levels of immunoglobulin genetic diversity
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/ncomms13642.pdf
Reference45 articles.
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3. Robinson, W. H. Sequencing the functional antibody repertoire--diagnostic and therapeutic discovery. Nat. Rev. Rheumatol. 11, 171–182 (2015).
4. Giudicelli, V., Chaume, D. & Lefranc, M. P. IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 33, D256–D261 (2005).
5. Aouinti, S., Malouche, D., Giudicelli, V., Kossida, S. & Lefranc, M. P. IMGT/HighV-QUEST statistical significance of IMGT clonotype (AA) diversity per gene for standardized comparisons of next generation sequencing immunoprofiles of immunoglobulins and T cell receptors. PLoS ONE 10, e0142353 (2015).
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