Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery-Reference-Cited by-同舟云学术

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Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery

Published:2024-06-06 Issue:1 Volume:16 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Dudzic Pawel¹,Chomicz Dawid¹,Kończak Jarosław¹,Satława Tadeusz¹,Janusz Bartosz¹,Wrobel Sonia¹,Gawłowski Tomasz¹,Jaszczyszyn Igor¹,Bielska Weronika¹,Demharter Samuel²,Spreafico Roberto³^ORCID,Schulte Lukas⁴,Martin Kyle⁵,Comeau Stephen R.⁵,Krawczyk Konrad¹^ORCID

Affiliation:

1. NaturalAntibody, Szczecin, Poland

2. Discovery Data Science, Genmab, Copenhagen, Denmark

3. Discovery Data Science, Genmab, Utrecht, The Netherlands

4. Global Computational Biology & Digital Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany

5. Biotherapeutics Discovery, Boehringer Ingelheim, Ridgefield, CT, USA

Funder

no funding associated

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2024.2361928

Reference56 articles.

1. Antibodies to watch in 2023

2. 2022 FDA approvals

3. High-Throughput DNA Sequencing Analysis of Antibody Repertoires

4. The antibody repertoire in evolution: Chance, selection, and continuity

5. Understanding the human antibody repertoire

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