Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer-Reference-Cited by-同舟云学术

Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF binding to a MYC enhancer

Published:2016-10-24 Issue:1 Volume:7 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Grampp Steffen,Platt James L.,Lauer Victoria,Salama Rafik^ORCID,Kranz Franziska,Neumann Viviana K.,Wach Sven,Stöhr Christine,Hartmann Arndt,Eckardt Kai-Uwe,Ratcliffe Peter J.^ORCID,Mole David R.,Schödel Johannes

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms13183.pdf

Reference57 articles.

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3. Mandriota, S. J. et al. HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell 1, 459–468 (2002).

4. Vanharanta, S. et al. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer. Nat. Med. 19, 50–56 (2013).

5. van Haaften, G. et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat. Genet. 41, 521–523 (2009).

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