Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo-Reference-Cited by-同舟云学术

Impact of FLT3-ITD location on sensitivity to TKI-therapy in vitro and in vivo

Published:2015-10-21 Issue:5 Volume:30 Page:1220-1225
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Arreba-Tutusaus P,Mack T S,Bullinger L,Schnöder T M,Polanetzki A,Weinert S,Ballaschk A,Wang Z,Deshpande A J,Armstrong S A,Döhner K,Fischer T,Heidel F H

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/leu2015292.pdf

Reference16 articles.

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3. Heidel F, Solem FK, Breitenbuecher F, Lipka DB, Kasper S, Thiede MH et al. Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain. Blood 2006; 107: 293–300.

4. Smith CC, Wang Q, Chin CS, Salerno S, Damon LE, Levis MJ et al. Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature 2012; 485: 260–263.

5. Kayser S, Schlenk RF, Correa Londono M, Breitenbuecher F, Wittke K, Du J et al. Insertion of FLT3 internal tandem duplication in the tyrosine kinase domain-1 is associated with resistance to chemotherapy and inferior outcome. Blood 2009; 114: 2386–2392.

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