Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

Author:

Arnold Steven E.,Arvanitakis Zoe,Macauley-Rambach Shannon L.,Koenig Aaron M.,Wang Hoau-Yan,Ahima Rexford S.,Craft Suzanne,Gandy Sam,Buettner Christoph,Stoeckel Luke E.,Holtzman David M.,Nathan David M.

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical)

Reference279 articles.

1. Snyder, H. M. et al. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimers Dement. 11, 710–717 (2015).

2. Montine, T. J. et al. Recommendations of the Alzheimer's disease-related dementias conference. Neurology 83, 851–860 (2014).

3. Stoeckel, L. E. et al. Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000Res. 5, 353 (2016).

4. Chatterjee, S. et al. Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia. Diabetes Care 39, 300–307 (2016).

5. Gao, C., Liu, Y., Li, L. & Holscher, C. New animal models of Alzheimer's disease that display insulin desensitization in the brain. Rev. Neurosci. 24, 607–615 (2013).

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