Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1-Reference-Cited by-同舟云学术

Transition-state analogue inhibitors of γ-secretase bind directly to presenilin-1

Published:2000-06-09 Issue:7 Volume:2 Page:428-434
ISSN:1465-7392
Container-title:Nature Cell Biology
language:en
Short-container-title:Nat Cell Biol

Author:

Esler William P.,Kimberly W. Taylor,Ostaszewski Beth L.,Diehl Thekla S.,Moore Chad L.,Tsai Jui-Yi,Rahmati Talat,Xia Weiming,Selkoe Dennis J.,Wolfe Michael S.

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology

Link

http://www.nature.com/articles/ncb0700_428.pdf

Reference47 articles.

1. Hardy, J. The Alzheimer family of diseases: many etiologies, one pathogenesis? Proc. Natl Acad. Sci. USA 94, 2095–2097 (1997).

2. Selkoe, D. J. Alzheimer’s disease: genotypes, phenotypes and treatments. Science 275, 630–631 ( 1997).

3. Selkoe, D. J. Translating cell biology into therapeutic advances in Alzheimer’s disease . Nature 399 A23–A31 (1999).

4. Vassar, R. et al. beta-secretase cleavage of Alzheimer’s amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735–741 (1999).

5. Sinha, S. et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402, 537–540 (1999).

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