Artificial intelligence for natural product drug discovery
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Published:2023-09-11
Issue:11
Volume:22
Page:895-916
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ISSN:1474-1776
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Container-title:Nature Reviews Drug Discovery
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language:en
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Short-container-title:Nat Rev Drug Discov
Author:
Mullowney Michael W.ORCID, Duncan Katherine R.ORCID, Elsayed Somayah S.ORCID, Garg NehaORCID, van der Hooft Justin J. J.ORCID, Martin Nathaniel I.ORCID, Meijer DavidORCID, Terlouw Barbara R.ORCID, Biermann FriederikeORCID, Blin KaiORCID, Durairaj JananiORCID, Gorostiola González MarinaORCID, Helfrich Eric J. N.ORCID, Huber FlorianORCID, Leopold-Messer StefanORCID, Rajan KohulanORCID, de Rond TristanORCID, van Santen Jeffrey A., Sorokina MariaORCID, Balunas Marcy J.ORCID, Beniddir Mehdi A.ORCID, van Bergeijk Doris A.ORCID, Carroll Laura M.ORCID, Clark Chase M.ORCID, Clevert Djork-ArnéORCID, Dejong Chris A., Du Chao, Ferrinho ScarletORCID, Grisoni FrancescaORCID, Hofstetter Albert, Jespers Willem, Kalinina Olga V.ORCID, Kautsar Satria A., Kim HyunwooORCID, Leao Tiago F., Masschelein JoleenORCID, Rees Evan R., Reher RaphaelORCID, Reker DanielORCID, Schwaller Philippe, Segler Marwin, Skinnider Michael A.ORCID, Walker Allison S., Willighagen Egon L.ORCID, Zdrazil BarbaraORCID, Ziemert Nadine, Goss Rebecca J. M.ORCID, Guyomard PierreORCID, Volkamer Andrea, Gerwick William H., Kim Hyun UkORCID, Müller RolfORCID, van Wezel Gilles P.ORCID, van Westen Gerard J. P.ORCID, Hirsch Anna K. H.ORCID, Linington Roger G.ORCID, Robinson Serina L.ORCID, Medema Marnix H.ORCID
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Reference230 articles.
1. Dobson, P. D., Patel, Y. & Kell, D. B. ‘Metabolite-likeness’ as a criterion in the design and selection of pharmaceutical drug libraries. Drug Discov. Today 14, 31–40 (2009). 2. Newman, D. J. & Cragg, G. M. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. J. Nat. Prod. 83, 770–803 (2020). 3. Koehn, F. E. & Carter, G. T. The evolving role of natural products in drug discovery. Nat. Rev. Drug. Discov. 4, 206–220 (2005). 4. Terlouw, B. R. et al. MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters. Nucleic Acids Res. 51, D603–D610 (2023). 5. Gavriilidou, A. et al. Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes. Nat. Microbiol. 7, 726–735 (2022).
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