Phase I study of TAS-102 treatment in Japanese patients with advanced solid tumours

Author:

Doi T,Ohtsu A,Yoshino T,Boku N,Onozawa Y,Fukutomi A,Hironaka S,Koizumi W,Sasaki T

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference17 articles.

1. Ansfield FJ, Ramirez G (1971) Phase I and II studies of 2'-deoxy-5-(trifluoromethyl)-uridine (NSC-75520). Cancer Chemother Rep 55: 205–208

2. Emura T, Nakagawa F, Fujioka A, Ohshimo H, Yokogawa T, Okabe H, Kitazato K (2004a) An optimal dosing schedule for a novel combination antimetabolite, TAS-102, based on its intracellular metabolism and its incorporation into DNA. Int J Mol Med 13: 249–255

3. Emura T, Suzuki N, Yamaguchi M, Ohshimo H, Fukushima M (2004b) A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA. Int J Oncol 25: 571–578

4. Fujiwara Y, Heidelberger C (1970a) Fluorinated pyrimidines. XXXVII. The incorporation of 5-trifluoromethyl-2'-deoxyuridine into the deoxyribonucleic acid vaccinia virus. Mol Pharmacol 6: 281–291

5. Fujiwara Y, Oki T, Heidelberger C (1970b) Fluorinated pyrimidines. XXXVII. Effect of 5-trifluoromethyl-2'-deoxyuridine on the synthesis of deoxyribonucleic acid of mammalian cells in culture. Mol Pharmacol 6: 273–280

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