Abstract
AbstractSevere diaphragm dysfunction can lead to respiratory failure and to the need for permanent mechanical ventilation. Yet permanent tethering to a mechanical ventilator through the mouth or via tracheostomy can hinder a patient’s speech, swallowing ability and mobility. Here we show, in a porcine model of varied respiratory insufficiency, that a contractile soft robotic actuator implanted above the diaphragm augments its motion during inspiration. Synchronized actuation of the diaphragm-assist implant with the native respiratory effort increased tidal volumes and maintained ventilation flow rates within the normal range. Robotic implants that intervene at the diaphragm rather than at the upper airway and that augment physiological metrics of ventilation may restore respiratory performance without sacrificing quality of life.
Funder
Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre
Muscular Dystrophy Association
U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering
Fondation SICPA, Lausanne Improvement fund, Lausanne University Hospital
Massachusetts Institute of Technology, School of Engineering, SMA2 Brown Fellowship
NSF | ENG/OAD | Division of Chemical, Bioengineering, Environmental, and Transport Systems
Publisher
Springer Science and Business Media LLC
Subject
Computer Science Applications,Biomedical Engineering,Medicine (miscellaneous),Bioengineering,Biotechnology
Reference56 articles.
1. Hutchinson, D. & Whyte, K. Neuromuscular disease and respiratory failure. Pract. Neurol. 8, 229–237 (2008).
2. Groth, S. S. & Andrade, R. S. Diaphragm plication for eventration or paralysis: a review of the literature. Ann. Thorac. Surg. 89, S2146–S2150 (2010).
3. Tripp, H. F. & Bolton, J. W. Phrenic nerve injury following cardiac surgery: a review. J. Card. Surg. 73, 218–223 (1998).
4. Leung, D. G. & Wagner, K. R. Therapeutic advances in muscular dystrophy. Ann. Neurol. 74, 404–411 (2013).
5. Kurtzke, J. F. Epidemiology of amyotrophic lateral sclerosis. Adv. Neurol. 36, 281–302 (1982).
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献