Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles-Reference-Cited by-同舟云学术

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Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

Published:2013-12-13 Issue:4 Volume:21 Page:582-593
ISSN:1350-9047
Container-title:Cell Death & Differentiation
language:en
Short-container-title:Cell Death Differ

Author:

Joshi P,Turola E,Ruiz A,Bergami A,Libera D D,Benussi L,Giussani P,Magnani G,Comi G,Legname G,Ghidoni R,Furlan R,Matteoli M,Verderio C

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/cdd2013180.pdf

Reference64 articles.

1. Herring A, Lewejohann L, Panzer AL, Donath A, Kroll O, Sachser N et al. Preventive and therapeutic types of environmental enrichment counteract beta amyloid pathology by different molecular mechanisms. Neurobiol Dis 2011; 42: 530–538.

2. Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Bohm G et al. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry 2006; 45: 12393–12399.

3. Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F et al. Small-molecule conversion of toxic oligomers to nontoxic beta-sheet-rich amyloid fibrils. Nat Chem Biol 2012; 8: 93–101.

4. Winklhofer KF, Tatzelt J, Haass C . The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. EMBO J 2008; 27: 336–349.

5. Benilova I, Karran E, De Strooper B . The toxic Abeta oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci 2012; 15: 349–357.

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