Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils-Reference-Cited by-同舟云学术

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

Published:2011-11-20 Issue:1 Volume:8 Page:93-101
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Bieschke Jan,Herbst Martin,Wiglenda Thomas,Friedrich Ralf P,Boeddrich Annett,Schiele Franziska,Kleckers Daniela,Lopez del Amo Juan Miguel,Grüning Björn A,Wang Qinwen,Schmidt Michael R,Lurz Rudi,Anwyl Roger,Schnoegl Sigrid,Fändrich Marcus,Frank Ronald F,Reif Bernd,Günther Stefan,Walsh Dominic M,Wanker Erich E

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.719.pdf

Reference49 articles.

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3. Harper, J.D. & Lansbury, P.T. Jr. Models of amyloid seeding in Alzheimer′s disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. Annu. Rev. Biochem. 66, 385–407 (1997).

4. Stefani, M. & Dobson, C.M. Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution. J. Mol. Med. 81, 678–699 (2003).

5. Chimon, S. et al. Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer′s β-amyloid. Nat. Struct. Mol. Biol. 14, 1157–1164 (2007).

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