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The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice

  • Published:2009-07 Issue:7 Volume:17 Page:1225-1233
  • ISSN:1525-0016
  • Container-title:Molecular Therapy
  • language:en
  • Short-container-title:Molecular Therapy

Author:

Gao Shan,Dagnaes-Hansen Frederik,Nielsen Ebbe Juel Bech,Wengel Jesper,Besenbacher Flemming,Howard Kenneth Alan,Kjems Jørgen

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference41 articles.

1. Key issues in non-viral gene delivery;Pouton;Adv Drug Deliv Rev,2001

2. Biodistribution of phosphodiester and phosphorothioate siRNA;Braasch;Bioorg Med Chem Lett,2004

3. Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides;Geary;Curr Opin Investig Drugs,2001

4. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality;Elmen;Nucleic Acids Res,2005

5. Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo;Mook;Mol Cancer Ther,2007

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