Studying paired patient tissue and blood enables insights into immunotherapy toxicity
Author:
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41591-024-02900-3.pdf
Reference5 articles.
1. Postow, M. A., Sidlow, R. & Hellmann, M. D. Immune-related adverse events associated with immune checkpoint blockade. N. Engl. J. Med. 378, 158–168 (2018). A review article that presents an overview of common and distinct features of IRAEs across organ systems.
2. Bai, X. et al. Early use of high-dose glucocorticoid for the management of irae is associated with poorer survival in patients with advanced melanoma treated with anti-PD-1 monotherapy. Clin. Cancer Res. 27, 5993–6000 (2021). This paper reports that patients with melanoma who receive high-dose steroids to treat IRAEs have worse overall survival.
3. Blum, S. M. et al. Immune responses in checkpoint myocarditis across heart, blood, and tumor. Preprint at bioRxiv https://doi.org/10.1101/2023.09.15.557794 (2023). A preprint manuscript from our research group on the biological underpinnings of checkpoint inhibitor-associated myocarditis.
4. Boland, B. S. et al. Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses. Sci. Immunol. 5, eabb4432 (2020). A study assessing clonal sharing among patients with ulcerative colitis finds T cell receptor sharing between intestinal and blood CD8+ T cell populations, similar to those described in our study.
5. Zubiri, L. et al. Effect of a multidisciplinary Severe Immunotherapy Complications Service on outcomes for patients receiving immune checkpoint inhibitor therapy for cancer. J. Immunother. Cancer 9, e002886 (2021). This paper presents an overview of the Massachusetts General Hospital Severe Immunotherapy Service and its effect on patient outcomes.
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